|BONE MARROW: ACUTE MONOCYTIC LEUKEMIA |
The second study produced an article entitled: 'The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors' was published in a recent issue of the journal Haematologica. This study sought a way to reactivate C/EBPα through the use of small molecule inhibitors where they found that histone deacetylase inhibitors had a positive connection. Histone deacetylases (HDAC's) are involved in epigenetic regulation so it is expected that they will be useful in treatments of AML which involves epigenetic repression of C/EBPα.
|Structure of the CEBPA protein|
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