The report is a collaboration of Chinese scientists entitled: 'Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma'. These scientists describe how they were able to perform targeted inactivation of Runx3 and show that this leads to adenoma formation and more rapid formation of adenocarcinoma in the lungs of mice. Furthermore Runx3 was observed to be frequently inactivated in human lung adenocarcinomas that had mutated K-Ras. Although this study focused on lung cancer it opens the possibility that RUNX3 could be similarly pivotal for other cancers.
|Structure of the RUNX3 protein|
Some information for this post was obtained from the Science Daily article: Scientists Find 'Missing Link' in Important Tumor Suppression Mechanism