|Structure of the BRD4 protein. |
Based on PyMOL rendering of PDB 2oss
The assay employed was previously described in a paper entitled: 'Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery.' It identifies the ability of bromodomains to bind to acetylated histone peptides via protein-protein interaction that can be detected using AlphaScreen technology.
We at BMG LABTECH are proud that our instruments could contribute in some way to this very interesting research!