One reason that cancers, such as glioblastoma, have evaded treatment is that they seem to use multiple pathways to achieve continual growth. As a result, inhibition of one pathway is insufficient to have the desired growth halting effect. The authors of the paper, which was recently published in Cancer Discovery, sought a target which regulates multiple pathways. They found that inhibiting diacylglycerol kinase alpha (DGK alpha), which had been linked to several pathways related to cancer biology, led to cell death in glioblastoma cells!
A single image of a brain using MRI. A bright blue color
where cancer metastasizes
by Dr. Leon Kaufman