Friday, January 18, 2013

Focus on: SLAS wrap up

It was great to see so many of you attending SLAS this week in Orlando, FL. There was plenty of excellent science and technology on display and BMG was happy that we were able to participate as a diamond sponsor for the event. Attendees came from around the world to take part in the 4 day event.

We at BMG were especially excited to meet with Hayley Jones and David Whalley, two scientist at MRC Technology in London. Both have been doing some exciting work with our PHERAstar FS and took the opportunity to share their work at SLAS.

Illustration of the pain pathway in René Descartes' Traite de l'homme (Treatise of Man) 1664. The long fiber running from the foot to the cavity in the head is pulled by the heat and releases a fluid that makes the muscles contract.
Hayley gave a poster entitled: Identification of and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor. The galanin 2 receptor (GalR2) is implicated in regulating pain reception, especially in regard to chronic nerve damage. However, since there are no high affinity small molecule compounds that activate GalR2) Hayley is investigating potential PAM's (positive allosteric modulators). Employing the HTRF IP-One assay from Cisbio and the PHERAstar FS from BMG LABTECH Hayley has succesfully performed the intitial screeen of 100,000 compounds and is now looking to perform some dose response analysis on the compounds. It is hoped that identification of PAM's for GalR2 will have therapeutic advantages including the retention of physiological response.

  • purine (spacefill)
David is in the early stages of his project and gave a poster entitled: Development of a High-Throughput Screening Assay to Identify Inhibitors of the de novo Purine Biosynthetic Pathway. He is looking for inhibitors of a bi-functional enzyme that is overexpressed in breast cancer. Since this enzyme is ATP dependent he was able to employ the Transcreener assay from Bellbrook Labs with detection performed by the PHERAstar FS to perform a high-throughput screen. He is now ready to screen a compound library with 100 K to 200 K compounds.

Great job by everyone in attendance! See you next year in San Diego!

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