Thursday, April 19, 2012

Inside Applications: Nephelometric Monitoring Growth of Candida albicans

- Light-Scattering laser nephelometry used for fungal growth determination and for measurement of drug solubility

- Monitoring the growth of Candida albicans in presence of antifungal agents

- Phase solubility diagrams of potential drug presented

Laser nephelometry, which measures light-scattering, has been shown to be a reliable technique for the measurement of drug solubility in 96-well plate format. BMG LABTECH´s NEPHELOstar Plus microplate reader can be used to investigate the effects of complexation on the drug antimycotic activity. Laser nephelometry can distinguish between the concentration at which the drug just goes into or just comes out of solution. This is presented in phase solubility studies. Furthermore nephelometry was used to monitor fungal growth.

Click here to read the entire application note: Nephelometric Monitoring Growth of Candida albicans Using BMG LABTECH’s NEPHELOstar

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