Thursday, March 15, 2012

Inside Applications: A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)

Epigentic Assay Graph Point Histone modifications caused by HDAC are strongly related to epigenetic regulation of transcription
Point HDAC inhibitors (HDIs) are a possible strategy in cancer therapy
Point Fluorescent HDAC activity and inhibitor assay was performed on a POLARstar OPTIMA microplate reader from BMG LABTECH
Post-translational histone modifications like acetylation play an important role in the epigenetic regulation of transcription. Determining the activity of recombinant HDAC1 using the POLARstar OPTIMA microplate reader from BMG LABTECH offers high precision and performance. Using Boc-Lys(Ac)-AMC as fluorescent substrate HDAC activity and inhibitor assays can be performed over a wide concentration range.

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