"High throughput scanning of metal chelators for neurodegenerative diseases" by Breno Pannia Espósito, Instituto de Química, Universidade de São Paulo, Brazil, was chosen as a furhter runner-up in the SPECTROstar nano competition.
The imbalance in the brain of some transition metal ions (iron, copper, manganese) is thought to be involved in the progression of some neurodegenerative diseases, although a precise mechanism of action has not been established. This laboratory researches redox-active plasmatic iron and it wants to investigate novel chelators that could decrease metal reservoirs within cells and blood-brain barrier models. Since most metal-chelating compounds are chromophoric, the UV-Vis absorbance ability of the SPECTROstar Nano can be used to find high affinity chelators that may be used to restore metalloneurochemical balance. A high-throughput, competition assay is proposed with iron- or copper-chromophore ligands and then cell toxicity will be tested via the MTT assay on possible therapeutic chelators.
Visit http://www.bmglabtech.com/promotion/high-throughput-scanning.cfm to read the entire proposal.