Friday, February 10, 2012

Focus Friday: Controlling the Atmosphere for Cell-based Microplate Assays

As cell-based experiments have grown in use in life science laboratories, they have transitioned into the microplate format. As a result, the need for proper atmospheric and environmental control within detection instrumentation has arisen. The Atmospheric Control Unit (ACU) from BMG LABTECH is an accessory that meets such a need. The ACU controls the environment within the microplate reader chamber using two independently regulated valves for both oxygen (O2) and carbon dioxide (CO2). Now all types of cell-based assays (mammalian, bacterial, yeast) can be performed within a microplate reader using their most ideal atmospheric condition, Furthermore, cellular conditions such as hypoxia or anoxia can be induced to mimic disease states like stroke, ischemia, cardiovascular, or wound healing.

The ACU’s unique two valve system is controlled by a built-in microprocessor, allowing for the complete and independent regulation of O2 and CO2. This ensures the conditions are kept constant while consuming the minimal amount of gases once equilibrium is reached. Any gas concentration combination is easily programmed and there is no need to change cylinders or gas supplies when changing either concentration.

The BMG LABTECH ACU is the most flexible gas control system available for a microplate reader. When used in combination with other microplate reader features, such as temperature control and shaking, users can reproduce most physiological cellular conditions. The ACU provides a true walk away, hands free, cellular assay solution for your microplate reader experiments. Applications include: mammalian cells, stem cells, hypoxia, cell viability, cell proliferation, tumor cells, migration studies, invasion assays, intracellular pH, angiogenesis, ischemia and reperfusion, to name a few.

With the Atmospheric Control Unit, BMG LABTECH provides a great solution for cell-based, microplate experiments.

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