Thursday, January 26, 2012

Applications Thursday: Novel use of SPECTROstar Nano to measure transparency in collagen constructs and human cornea

Runner Up in the SPECTROstar Nano Competition:
Dr. Hannah Levis UCL Institute of Ophthalmology, London, UK
Novel use of SPECTROstar Nano to measure transparency in collagen constructs and human cornea

This research project is a multidisciplinary project in tissue engineering and ocular stem cell biology. The goal is to engineer an alternative cornea epithelium substrate to replace amniotic membrane as a carrier for the epithelial cells. Plastic compressed collagen constructs provide an optimal substrate to allow production of an intact and healthy corneal epithelial layer. These researchers propose to use the SPECTROstar Nano, amongst other things, to measure quantitatively the transparency of the new plastic collagen constructs. As the researchers point out, “A key commercial goal of this RAFT (Real Architecture For 3D Tissue) System is to increase the use of 3D cell culture constructs within the broader pharmaceutical and biotech secondary screening market.” Many users of this technology will also be interested in using the SPECTROstar Nano for additional assays such as MTT cell proliferation, ELISA tests, and DNA/RNA/protein quantitation.

For more information, read the entire proposal here:
Novel use of SPECTROstar Nano to measure transparency in collagen constructs and human cornea

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