Fun Fact: Did you know that DNA has tendencies to break at more “fragile sites”?
It is these regions, that when under replication stress such as in cancer cells, that tend to break more often than others, leading to further defects. This is the first time to show that abnormal replication of these fragile sites leads to further DNA breakage and possible mutations. This opens a whole new area of research for cancer fighting drugs. http://www.sciencedaily.com/releases/2011/07/110719094023.htm