Friday, September 30, 2011

Focus on AlphaScreen®

AlphaTechnology, comprised of AlphaScreen®, AlphaLISA® and Surefire®, have become one of the most important detection technologies in microplate reading today. It is a unique assay technology that measures the interaction of two molecules bioconjugated to donor and acceptor beads. When interactions occur between these molecules, the beads are brought close enough to cause a chemical reaction. Upon laser excitation at 680 nm, a singlet oxygen transfer occurs that leads to a strong light emission between 520 to 620 nm, which is directly proportional to the amount of binding.

BMG LABTECH has resonded to the needs of our customers and their demands for sensitive AlphaScreen® detection capabilities. In 2005, users wished to have AlphaScreen® technology and BMG LABTECH became an early adopter of AlphaScreen® with the addition of a solid state laser on our PHERAstar microplate reader.  In 2008, we designed a specialized measurement mode and optical system to provide the FLUOstar Omega and POLARstar Omega microplate readers withAlphaScreen®, AlphaLISA® and Surefire® performance that rivals any HTS microplate reader.  And, with the PHERAstar FS we now have our third generation AlphaScreen® systems that boast superior speed and sensitivity to ensure that you get the most out of your AlphaScreen® assays. 

For more information on AlphaTechnology and to find application notes as well as a list of BMG LABTECH microplate readers that can perform measurements in these detection modes, see http://www.bmglabtech.com/technology/alphascreen.cfm

AlphaLISA, Surefire and AlphaScreen are registered trademarks of PerkinElmer, Inc.

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